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Metformin treatment with concentrations of 10, 25, and 50 M significantly restored chondrocyte viability suppressed by H 2 O 2 exposure, and 50 M metformin was chosen for further studies (Fig

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Disruption of specific factors, such as Taf4 inactivation, leads to loss of -cell identity and disrupts metabolic and inflammatory pathways (Kleiber et al., 2021)