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3i and Supplementary Fig

Building upon this core machinery, the glucosinolate pathway involves three additional enzymatic modules completing metabolic transformation: (1) CYP83A1 converts aliphatic aldoximes to thiohydroximates, (2) UGT74B1 mediates glycosylation of sulfated intermediates (requiring prior sulfation by SOT17/18), (3) the myrosinase-TGG1/2 system, in concert with epitope-specific proteins (ESPs), hydrolyzes stored glucosinolates into bioactive compounds like SFN upon tissue damage (41)

Jahn, S

Using this combination in a mouse xenograft model led to suppressing tumor development through stimulating retinoic acid receptors beta (RAR-), and preventing vessel formation (82)

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