The pharmaceutical industry abandoned GH secretagogue development in the early 2010s not because the compounds don't workPhase 3 trials consistently demonstrated GH and IGF-1 elevationbut because the therapeutic window for meaningful clinical outcomes (muscle preservation in cachexia, bone density improvement in osteoporosis) was too narrow relative to metabolic side effects like glucose intolerance
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Een zeer interessante observatie is dat de hoeveelheid van deze peptide in het bloed en weefsel leeftijdsafhankelijk is
Furthermore, there was no detectable complex of Au 15 SG 12 -Ao with the non-oxidized protein (Fig