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Association of vitamin B12 deficiency in people with type 2 diabetes on metformin and diabetic peripheral neuropathy Nature article: Shows prolonged metformin use correlates with lower B12 and more severe diabetic neuropathy
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Rare adverse events that might emerge in large systematic studies could remain invisible in informal self-experimentation
once mixed, refrigerate at 28 C and do not freeze the solution
B12 shots supply vitamin B12 as methylcobalamin or cyanocobalamin, typically given intramuscularly into the deltoid, supporting red blood cell formation, myelin and nervous system health, and the metabolism of homocysteine, a process that can falter with vegan diets, malabsorption, or medications like metformin
