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Understanding this dose-response curve helps explain why the standard protocol includes dose titration
It cushions and lubricates joints, helps reduce friction, and promotes smooth movemen
This makes it a less intimidating option for many patients, especially those with a fear of needles or who struggle with injectable therapies
Mutations in PDI and ERp57 were also described in ALS patients, but are thought to be more of a risk factor than directly causative of neurodegeneration (Woehlbier et al., 2016)
Ethics declarations Ethics approval and consent to participate The study was approved by the Ethics Committee of Zhengzhou University Peoples Hospital
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