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Natural compounds as source of aldose reductase (AR) inhibitors for the treatment of diabetic complications: a mini review
Preserved pulsatile architecture
doi:10.3389/fimmu.2025.1639732 29
Diabetic neuropathy relief: strong evidence Alpha-lipoic acid (ALA) is one of the most well-researched supplements for diabetic peripheral neuropathy, a common complication of diabetes that can lead to nerve pain, tingling, numbness, and weakness in the limbs.19 Several clinical trials, particularly those involving intravenous ALA, have shown that doses of 600mg per day can reduce these symptoms over a matter of weeks.20 21 ALAs proposed benefit lies in its antioxidant activity
PMID 6361812
Depleted intracellular glutathione has been linked to Th1/Th2 immune imbalance and increased pro-inflammatory cytokine activity, which may contribute to autoimmune thyroid disease progression (Drge, 2002)
