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In clinical trials, 100% of healthy volunteers experienced this chromaturia with administration of 5g hydroxocobalamin with other common effects including erythema, rash (predominantly acneiform appearance) and increased blood pressure

When NF-kB is overactivated (as it is in chronic inflammatory conditions), it triggers a cascade of pro-inflammatory cytokines including TNF-alpha and IL-6

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What has not been established is that liposomal glutathione consistently provides: Greater cellular uptake than S-acetyl glutathione in humans More direct delivery to target tissues Faster or more clinically meaningful effects Better symptom, disease or longevity outcomes No robust human head-to-head trial has established a universal winner