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The datasets had already been robust multi-array average-normalized in batches using the makecdfenv, affy and limma R packages, and batch-corrected using the ComBat method in the sva R package

Osowiecka K, Myszkowska-Ryciak J

The effects of the oral supplementation of L-Cystine associated with reduced L-Glutathione-GSH on human skin pigmentation: a randomized, double-blinded, benchmark- and placebo-controlled clinical trial

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Co-enzyme B12 also interacts with the enzyme methionine synthase (5-methyltetrahydrofolate-homocysteine methyltransferase), required for the conversion of homocysteine to methionine, which is essential for folic acid metabolism and the formation of thymine, which is a component of DNA

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