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Fatigue is actually listed as a common adverse reaction in the Summary of Product Characteristics (SmPC) for some GLP-1 receptor agonists, particularly those used at higher doses for weight management such as semaglutide 2.4mg (Wegovy) and liraglutide 3mg (Saxenda)

Clinical Significance: These data suggest that orforglipron could provide an oral alternative to injectable GLP-1 therapies

When done properly, compounding serves a vital public good, said Cook

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