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While both drugs are effective, tirzepatide's dual-agonist mechanism, targeting both GIP and GLP-1 receptors, is widely believed to be the reason for its weight loss results in clinical studies

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What it cannot do is tell your muscles to stay

Medically reviewed by Dr Sultan Linjawi, Endocrinologist & Diabetes Specialist January 2026 What is Ozempic (Semaglutide)

Flushing Temporary warmth or flushing shortly after injection, usually brief

As of the time of writing, retatrutide has not received marketing authorisation from the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency (EMA) for use in the United Kingdom