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The novel use of the internal reference, LR3, spiked into the analytical samples allows for the entire workflow of the assay, sample preparation to LC-MS/MS detection, to be monitored and provides quality assurance of the assay performance

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The TRIUMPH-4 Phase 3 trial in obesity with knee osteoarthritis later reported 28.7% mean weight loss at 68 weeks with retatrutide 12 mg/week, and identified a dose-related dysesthesia (nerve-tingling) signal in 8.8% of 9 mg and 20.9% of 12 mg patients (Bays et al., 2025)

doi:10.1007/s00018-022-04562-1 NLM

Drug interactions and safety