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Growth hormone reserve capacity diminishes progressively after age 30, and patients over 50 show significantly blunted GH response to GHRH stimulation
The levels of Mmp13 , Timp1 , PAI-1 , Tgf and Col3a1 , were significantly reduced by liraglutide treatment in female SKO mice, consistent with the histological observations ( Figure 3E )
10.1038/nature08980 Nature 46 KimuraK
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