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The vacuum insulation extends cooling time to 12-18 hours, rivaling the performance of dedicated medical coolers at a fraction of the cost

Nature 604:697707 Duan K, Premi E, Pilotto A, Cristillo V, Benussi A, Libri I, Giunta M, Bockholt HJ, Liu J, Campora R, Pezzini A, Gasparotti R, Magoni M, Padovani A, Calhoun VD (2021) Alterations of frontal-temporal gray matter volume associate with clinical measures of older adults with Covid-19

Poor storage means degraded medication, which means reduced efficacy, which means the dose you think you are getting is not the dose your body receives

This cost differential is a significant consideration for anyone evaluating long-term protocol sustainability

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