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Aging 12 , 336338 (1991)

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The cyanobenzyl group at the N1 position of the pyrimidine-2,4-dione compounds is strategically placed in the S 1 domain, and the nitrile group forms a hydrogen bond with Arg125

Overload of mitochondria with ammonium instigates over-production of reactive oxygen species and opening of mitochondrial permeability transition pore, which further damages astrocytes and induce astrocyte swelling

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