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noted that charged residues strongly contribute to the differences in interaction energy by IgG subclass, whereas hydrophobic interactions are approximately equal

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However, despite its effectiveness, AmB often fails to achieve complete fungal clearance, and relapses are common (Guidelines for The Diagnosis, Prevention and Management of Cryptococcal Disease in HIV-Infected Adults, Adolescents and Children: Supplement to the 2016 Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection, 2018)

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