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Furthermore, the PfGrx-catalyzed oxidation of roGFP2 is more than four orders of magnitude faster than the uncatalyzed reaction with GSSG and occurs two orders of magnitude faster via the glutathione-dependent monothiol mechanism than by the glutathione-independent dithiol mechanism (Fig

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This excess iron accelerates lipid peroxidation, aggravating tissue damage ( 2.4 The role of hypoxia in ferroptosis induced ARDS A common ARDS symptom, hypoxia, worsens lung damage in a number of ways