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The following framework helps evaluate what evidence actually supports this intervention and where gaps remain significant

demonstrated that AR mice treated with sinomenine showed a reduction of rubbing and sneezing also reduction in the eosinophils levels in the nasal mucosa, a reduction in the IgE, IL-4, and IFN- levels in the serum, and an increase in the TGF- expression in the serum and nasal mucosa ( 3.1.8 Warifteine Warifteine, an bisbenzylisoquinoline-type alkaloid discovered in Cissampelos sympodialis Eichler [Menispermaceae], has shown the ability to modulate the allergic profile in a model of chronic AR

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[PMID: 10352386] PubMed record related to this compound for laboratory literature review

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