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Although cortical volumetric bone mineral density (BMD) and mineral concentration remained unchanged, the findings suggest that GHS treatments can lead to an increase in bone size without necessarily impacting bone density

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therefore, individuals with obesity often exhibit eating behaviors characterized by the consumption of larger portions, energy-dense foods, and increased snacking behavior (104)

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Robust, head-to-head studies are needed to clarify the therapeutic potential and mechanistic diversity of these compounds before their clinical application in DOR management can be meaningfully assessed