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Summary: This phase 3a, double-blind, randomized trial evaluated the combination therapy in adults with obesity and type 2 diabetes
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Supporting normal detoxification pathways
Slowing the ramp to the label cadence (2.5 mg start, 2.5 mg steps, four-week holds) dropped that to mid-single digits at every maintenance dose, at no cost to the 12-week result, and the dedicated slow-titration trial reached placebo range. Reaching 15 mg is not the problem
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