This can result in an intensified or prolonged high sensation, which may be desirable for some but potentially concerning for others
Here is what it actually means
Schmid, N
The clinical translation of these trial results, which will be important for the comparison of GLP-1RAs with SGLT2 inhibitors in the treatment of patients with heart failure and a preserved ejection fraction, remains to be determined
( GLP-1 RAs recently appearing on the market, in particular liraglutide, semaglutide and tirzepatide (a GIP/GLP-1 RA dual agonist) seek to overcome the problem of the short plasma half-life of native GLP-1 through (i) changing the amino acid sequence of the peptide so that it is no longer broken down by DPP-4, and/or (ii) attaching a long acyl chain to the peptide, thus allowing it to bind to albumin, and avoid rapid elimination via the kidney
Animal models have demonstrated that GLP-1 RAs reduce drug-seeking behavior and attenuate conditioned place preference for substances such as alcohol, nicotine, and cocaine (32)