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Dual-targeted delivery of doxorubicin by mesoporous silica nanoparticle coated with AS1411 aptamer and RGDK-R peptide to breast cancer in vitro and in vivo
The study protocol was approved by the ethics committee of Louisiana State Health Sciences Center-Animal Care Committee (Animal Care protocol number P-15-006), and all the methods were carried out following the approved guidelines
This work was partially funded by the DFG priority programme SPP 1710 (Grant DE 1431/8-1 to M.D
These groups received intravenous treatments of PBS, oridonin, orid-liposome, orid-liposome-MAL, TLR2 pep-orid-liposome at a dose of 5 mg/kg, or PBS as control every other day
Reconstitution B: 5 mg vial + 3 mL BAC water (1.67 mg/mL) more BAC water for larger, easier-to-measure draws
N.AlexanderJ
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