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The p27 protein can inhibit the transduction of the rho-associated kinase (RhoA) signaling pathway, consequently reducing the migratory and invasive capacity of tumor cells [76]

Following this, they were washed with PBS and permeabilized with 0.3% (v/v) Triton X-100 (Sigma-Aldrich) solution for 5 min

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The ominous octet, which includes 8 key pathophysiologic defects found to be present in T2D, is illustrated in Figure 1

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