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GLP-1 agents have modest effects on colonic motility, but the data are not strong enough to issue a blanket reassurance

Gastric emptying normalizes, appetite-regulating hormones return to pre-treatment patterns, and the metabolic advantages conferred by weight loss begin to diminish as weight is regained

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Single-cell multi-omics and spatial transcriptomics will define spatiotemporal immunological heterogeneity at the lesion level, while lung-on-a-chip platforms reproducing the cigarette smoke microenvironment (143) enable high-throughput screening of upstream interceptors (Anticalins, RORt inhibitors), downstream node-specific inhibitors (ACT1, p38 MAPK), and adjunctive modulators (NR1D1 agonists, NAD + precursors, SCFA-based microbiome therapies)