Enzymatic-stability characterization of GH fragments
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Concerning the second aspect, although SV2A expression is constant inside synaptic vesicles and presents a small intervesicle variation (Mutch et al., 2011), the number of synaptic vesicles in the presynapse is closely related to synaptic activity and functionality (Valtorta et al., 1990
This metabolic imbalance contributes to increased lipid peroxidation, as indicated by high malondialdehyde (MDA) levels ( These mitochondrial impairments not only compromise energy production but also act as pro-inflammatory stimuli, promoting chronic neuroinflammation through dysregulated mitochondrial signaling and innate immune response
