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de Beeck, K

Changes in organismal nutritional state, such as those induced by fasting or starvation ( FGF21 locus via well-characterized nutritional and metabolite-responsive transcription factors, including fatty acid-responsive nuclear hormone receptors peroxisome proliferator-actived receptor- (PPAR) and PPAR ( FGF21 appears to be mainly synthesized in the liver ( In mice, -Klotho is primarily expressed across metabolic tissues including liver, pancreas, and adipose tissue ( FGFR2c and KLB (the gene encoding -Klotho) are induced upon exposure to FGF21 or an FGF21 analog, consistent with enhanced sensitivity to FGF21s metabolic effects ( In humans, FGFR1c is also the predominantly expressed receptor in adipose tissue, with mRNA levels up to two orders of magnitude higher than for FGFR2c or FGFR3c ( FGF21, FGFR1c , FGFR2c , and FGFR3c are also expressed in skeletal muscle ( FGFR2c and, to a lesser extent, FGFR3c are expressed basally in liver ( FGFR2c is more highly expressed in NAFLD relative to healthy liver ( FGF21 , KLB , FGFR1c , and FGFR3c in the liver, although FGFR2c remains the most highly expressed of FGF21s receptors in the liver

doi:10.1086/666606 4 Wood JM, et al

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PMID: 2511718