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The main risks include gastrointestinal side effects such as nausea, constipation, and abdominal pain that may be difficult to distinguish from diverticulitis symptoms

All methods are reported in accordance with ARRIVE guidelines

Symptoms such as persistent or severe abdominal pain, significant changes in urination, or a rash combined with difficulty breathing should be treated as a medical emergency

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AOD9604 free base and AOD9604 acetate should not be treated as analytically identical bulk drug substances

Nevertheless, increasing proof indicates that metformin primarily acts on the gastrointestinal system