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Yes, absolute patient safety is our highest priority
If confirmed pancreatitis occurs, you shouldnt restart semaglutide
SURPASS-4 showed that tirzepatide not only improved glycemic control but also potentially offered cardiovascular benefits, with a 20% reduction in the risk of major adverse cardiovascular events compared to insulin glargine [8]
Most patients need long-term or indefinite treatment to maintain weight loss
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( GLP-1 RAs recently appearing on the market, in particular liraglutide, semaglutide and tirzepatide (a GIP/GLP-1 RA dual agonist) seek to overcome the problem of the short plasma half-life of native GLP-1 through (i) changing the amino acid sequence of the peptide so that it is no longer broken down by DPP-4, and/or (ii) attaching a long acyl chain to the peptide, thus allowing it to bind to albumin, and avoid rapid elimination via the kidney
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