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This pulsatility is physiologically importantGH receptor sensitivity, downstream signaling responses, and metabolic effects all depend on intermittent rather than continuous stimulation

The specificity of the response was determined by treatment with an IGF-1R specific inhibitor, Picropodophyllin (PPP) that showed reduced BCL2 levels in GNE knockdown cells indicative of apoptotic response (Fig

DeChiara TM, Robertson EJ, Efstratiadis A