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A systematic review of drug-drug interactions with GLP-1RAs found that most co-administered oral drugs did not experience clinically significant changes in total exposure (AUC), although reduced peak concentrations (Cmax) and delayed time to peak (Tmax) were commonly observed, particularly for drugs with high solubility and permeability (108)

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Phung LT, Sasaki A, Lee HG, Vega RA, Matsunaga N, Hidaka S, Kuwayama H, Hidari H