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Child-Pugh A (mild impairment, score 5-6)

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Serious adverse events have not been reported in the preclinical toxicity literature, which found no identifiable lethal dose across four species by Xu 2020

In the absence of aspirin (left panel), arachidonic acid (AA) that is formed by phospholipase A2 breakdown of membrane phospholipids gains access to the active site of COX via a hydrophobic channel

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