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Clinicians should treat adherence to GLP-1 treatment as an important outcome in its own right not an afterthought, Al-Aly said

41, 42 The disparity in the ETC findings between muscle and fibroblast culture can be explained by the alternative use of citrate synthase, the first enzyme in the TCAC, for metabolizing propionyl-CoA

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In cells that have significant malic enzyme activity, this enzyme could play a critical anaplerotic role by replenishing oxaloacetate so the TCA cycle can progress