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Each carries different requirements for oversight, testing, and adverse-event reporting
12.2 Pharmacodynamics Semaglutide lowers fasting and postprandial blood glucose and reduces body weight
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Related GI injuries that qualify include ileus (impaired bowel function where the intestines stop moving food through), intestinal obstruction, and severe gallbladder complications including the need for gallbladder removal after tirzepatide use
The magnitude of liver fat reduction exceeded predictions based solely on weight loss, suggesting direct hepatic effects beyond indirect benefits of fat mass reduction
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