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Optimized production of insulin variant, a recombinant platelet aggregation inhibitor, by high cell-density fermentation of recombinant Escherichia coli

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Furthermore, an increased plasma von Willebrand factor is found in hyperhomocysteinemic subjects bearing premature arterial disease (Freyburger et al, 1997) and, of major relevance, acute methionine loading induced moderate hyperhomocysteinemia results in a significant increase in von Willebrand factor (Constant et al, 1999)

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