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FAK overexpression has also been shown to have synergistic effect with HGF on cell transformation (Chan et al, 2002)

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Letkiewicz, S

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The two reasons are that CBS is activated by estradiol and betaine (Bet), which is twice as high in females compared to males because the enzyme PEMT [Figure 1] is activated by a factor of 2.3 in menstruating females

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