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For instance, IGF-1 is made in the liver, hence an undiagnosed precancerous liver disease could have prevented the liver from producing normal levels of IGF-1. The study demonstrates the power of using population-level approaches to assess the extent to which risk factors apply across the entire cancer spectrum

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However, this advantage is contingent upon rigorous demonstration of exposureresponse relationships and the avoidance of overgeneralized claims based solely on preclinical data

Total and regional appendicular skeletal muscle mass prediction from dual-energy X-ray absorptiometry body composition models