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Komsuoglu Celikyurt I, Mutlu O, Ulak G, Uyar E, Bekta E, Yildiz Akar F, et al

A full medical evaluation at a trusted medical spa or by an obesity medicine doctor ensures safe use

We propose staged translation: initial human trials using systemic IV or intranasal delivery, reserving direct CNS approaches for refractory cases

Starting at a lower dose and gradually increasing may allow the body to adjust better, reducing the severity of gastrointestinal side effects

And that timeline isn't negotiable

Fiscal Impact of Expanded Medicare Coverage for GLP-1 Receptor Agonists to Treat Obesity was published in JAMA Health Forum in April 2025