Commercially available enzyme-linked immunosorbent assays (ELISA) were used for determination of total GLP-1 (736 and 936) (ALPCO, Salem, NH), GLP-2 (133 and 333) (Merck Millipore, Burlington, MA) and DPP4 (R&D Systems, Minneapolis, MN) plasma concentrations and were carried out according to the manufacturers instructions
Theyre not recommended if you have: Gastroparesis or severe GI conditions A personal or family history of medullary thyroid carcinoma or MEN2 genetic syndrome A history of pancreatitis Pregnancy or are breastfeeding Diabetic retinopathy (risk of worsening with rapid glucose drops) Always share your full health history with your providertransparency is critical for safe recommendations
This is particularly beneficial for patients struggling with emotional eating or those who find it challenging to resist tempting foods
Mechanistically, finasteride has been proven to be 5-R2 inhibitor by acting on alternative substrate for 5-R2 which is initially bound to highly stable complex of enzyme-bound NADP-dihydrofinasteride
de Menezes Ettinger JE, Azaro E, de Souza CA, et al
J Ovarian Res 8:32
