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Many participants experienced gastrointestinal side effects including abdominal pain, diarrhoea, nausea and vomiting, acid reflux and constipation, which varied in severity

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Side effects included nausea (39% of patients), diarrhea (25%) and vomiting (28%) [29] Overall, orfoglipron achieves comparable weight loss with other GLP1R agonists such as semaglutide and Rybelsus, but has a slightly better side effect profile and achieves weight loss in a shorter period of time

Energy balance mechanisms: Evaluation of hormone-linked metabolic processes

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