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The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1
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Mechanistic literature demonstrates that IGF-1 supports satellite cell activation, myogenic differentiation, and regenerative remodeling, which is why IGF-1-linked markers are routinely tracked in preclinical studies involving this combination [7]
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10.1016/j.bmcl.2013.09.071 54 LopezO
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