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Nausea and Digestive Changes Oral HRT can cause stomach upset, especially when taken on an empty stomach

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doi:10.1016/0006-2952(76)90004-6

GLP-1 receptor agonists like semaglutide and tirzepatide act on incretin pathways through GLP-1 and GIP receptors, with central appetite suppression and slowed gastric emptying as primary mechanisms

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