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Smoking: Tobacco use lowers HDL (good cholesterol), which helps remove LDL from the bloodstream [1][2][4]

[1] Kahathuduwa CN et al

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Jia L, Qu P, Zhao Y, Bai L, Ren H, Cheng A

Overexpression of seleno-glutathione peroxidase by gene transfer enhances the resistance of T47D human breast cells to clastogenic oxidants