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Proposed mechanisms of TB-500: TB-500 is primarily discussed for its role in cell migration and cytoskeletal remodeling

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Stevens-Johnson Syndrome: A rare allergic reaction to certain drugs which can result in painful rash and blisters and can potentially be life-threatening

Furthermore, because some NAPQI is created regardless of the function of the other 2 pathways, failure in the glutathione-dependent pathway is expected to result in the accumulation of NAPQI and subsequent toxicity, even if the other 2 pathways are functional.It is not surprising that both sulfation- and glutathione-dependent pathways are aberrant in the same population because they are metabolically connected [41,72,73]

Washington, DC: National Academies Press

Laser and other light-based therapies are being evaluated as potential therapies in refractory cases, although they carry the risk of worsening the condition in some cases.[] Recently, several systemic agents have been introduced for the treatment of melasma, most often as adjuncts to the established therapeutic modalities