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Oral reduced glutathione (L-GSH) is rapidly hydrolyzed by intestinal -glutamyl transpeptidase (-GT) into its three constituent amino acids glutamate, cysteine, and glycine before significant systemic absorption can occur

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Notably, conventional antioxidant therapies, including vitamins C and E or pharmacological Nrf2 activators, have shown disappointing clinical efficacy due to poor bioavailability, inadequate retinal delivery, and inability to neutralize sustained oxidative insults (37, 173, 174)