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A class-level NMA was conducted to estimate the incremental benefit of tirzepatide and GLP-1RAs over placebo, and an agent-level NMA was conducted to explore differences between tirzepatide and individual GLP-1RA agents

La ADA/EASD51 recomienda que la eleccin del segundo o tercer frmaco sea centrada en el paciente y se consideren las comorbilidades, el riesgo de hipoglicemia, el peso, los potenciales efectos secundarios, la eficacia, el costo, y las preferencias del paciente, sin recomendar ningn frmaco de los actualmente disponibles sobre otro

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May cause digestive problems

They stimulate so little muscle growth that its almost undetectable, says Israetel

Per-meal threshold: Aim for at least 30-40 grams of protein per meal across 3-4 meals daily