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These results raise the possibility that the direct anti-tumor effects of METAP2 inhibition contribute more than its indirect effects on host metabolism (e.g., weight loss, insulin sensitization) to explain superior tumor growth inhibition relative to tirzepatide
This content may reference compounded medications such as Semaglutide and Tirzepatide, which are prepared by licensed U.S.-based compounding pharmacies
For waist circumference, subgroup analyses showed that the high weekly semaglutide dosage group had a greater reduction on waist circumference compared with the low dose group (P for interaction =001)
[PubMed 15784664] 25
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