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9,353,354,355 Specifically, the increased gluconeogenesis and decreased glycogen synthesis in hepatic IR results in fasting hyperglycemia that increases total TG levels and blood pressure (BP), reduces HDL-C levels, and increases the risk of thrombosis formation

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This discouraged the pharmaceutical industry from developing such drugs and undermined the FDA's willingness to approve them

Individuals with a BMI of 30 kg/m or higher may qualify directly, while those with a BMI of 27 kg/m or higher may be eligible if they have weight-related health conditions like hypertension, type 2 diabetes , elevated cholesterol, or obstructive sleep apnea

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