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The presence of compounds like melittin, phospholipase A2, and biogenic amines in BV has been a subject of interest, with melittin, in particular, being a major toxin known for its cytotoxic effects (Shi et al., 2022)
Moreover, agrin-treated pericytes exhibited elevated levels of ROS and Fe 2+ , along with reduced expression of GPX4 and FTH1, thereby promoting ferroptosis, suppressing pericyte proliferation, and compromising blood-brain barrier function
Propagation is attenuated by iron chelation and accelerated by iron supplementation, consistent with a critical role for iron-dependent Fenton chemistry
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DOI: org/10.1016/j.bbagen.2012.09.008 6
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