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Rate constants for mammalian glutaredoxins and poplar GrxS12 range from 2.5 10 4 to 2 10 6 M 1 s 1 and also support a rate-limiting reductive half-reaction 19,20,21,37

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According to Mayo Clinics drug and supplement reference, intramuscular B12 (the form used in MIXTs B12 injection protocols) is well-established for restoring B12 status quickly in clinically deficient patients and is often used when oral supplementation is poorly absorbed

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Biodistribution of LSC-Exo in mice All the mouse experiments were approved by the animal ethical committee and experimental procedures were performed in accordance with the guidelines of the Institutional Animal Care and Use Committee (IACUC) at North Carolina State University under protocol # 19-806-B

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