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Additional mechanistic studies are needed to confirm these assumptions

However, due to the limited number of participants, plausible explanations for this observation remain unclear

Upper Arm: The back of the upper arm can also be used, though its often easier if someone else helps administer the injection

The FDA has approved several GLP-1 receptor agonists for type 2 diabetes management and, in some cases, chronic weight management

A 2025 Diabetes Care commentary describes physicians using multidose pens for fractional titration below the FDA-approved starting dose specifically for GI tolerability (Kom et al., 2025)

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