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The ability of hydroxocobalamin to rapidly scavenge and detoxify cyanide by chelation has resulted in several acute animal and human studies using systemic hydroxocobalamin doses at suprapharmacological doses as high as 140 mg/kg to support its use as an intravenous (IV) treatment for cyanide exposure

The most commonly reported adverse effects were mild to moderate headache and gastrointestinal symptoms including diarrhea, flatulence, nausea, and increased appetite

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This limitation of fat cell gain may also be due to the suggestions by Heffernan et al